Professionnal Experience
NB: The Oncoflam team joined a new research center in 2016 as the team SYNATAC
NB: The Thinakaran Lab moved to USF Neuroscience Institute /Byrd Alzheimer Center & Research Institute, Tampa, Florida
Research Associate
December 2018 - Present
Research Associate in the Polymenidou group, at the University of Zurich.
Aim1: Developing new models to decipher pathological mechanisms involved in TDP-43 associated pathologies
Aim2: Testing potential therapeutics for TDP-43 associated pathologies
Publication related:
https://pubmed.ncbi.nlm.nih.gov/34806807/
https://pubmed.ncbi.nlm.nih.gov/34021139/
https://pubmed.ncbi.nlm.nih.gov/34021132/
https://pubmed.ncbi.nlm.nih.gov/34309222/
Post-doctoral Scholar
July 2014 - November 2018
Post-doctoral scholar in the Thinakaran lab, at the University of Chicago.
Aim1: BIN1 physiological roles in the brain in myelination process and synaptic plasticity, learning and memory.
Aim2: BIN1 pathological implication in Amyloid pathology and/or Tau pathology
Aim3 (minor): Deciphering BACE1 trafficking regulation under different states of synaptic activity.
Publication related:
https://pubmed.ncbi.nlm.nih.gov/32160554
https://pubmed.ncbi.nlm.nih.gov/30692199
https://www.ncbi.nlm.nih.gov/pubmed/30506549
https://www.ncbi.nlm.nih.gov/pubmed/27488240
https://www.sciencematters.io/articles/201611000018
https://www.ncbi.nlm.nih.gov/pubmed/29078331
Post-doctoral Fellow
January 2014 – June 2014
Post-doctoral Fellow in Lyon Neuroscience Research Center in the ONCOFLAM team (Neuro-oncology and neuro-inflammation) Lyon, France
Aim: Elucidate the impact of auto-antibodies (limbic encephalitis) in synaptic remodeling, receptors internalization and trafficking and signaling pathway implicated.
Publication related:
https://www.ncbi.nlm.nih.gov/pubmed/22544902
PhD Student
October 2010 – December 2013
PhD student in Lyon Neuroscience Research Center in the ONCOFLAM team (Neuro-oncology and neuro-inflammation) Lyon, France under Claire Meissirel’s supervision (PhD, CR1 INSERM).
Aim: Deciphering the role of VEGF in the modulation of NMDAR activity, surface expression and localization in hippocampal pyramidal cells. We demonstrated a VEGF-dependent mechanism for regulating NMDAR function and localization at synaptic sites.
Publication related:
https://www.ncbi.nlm.nih.gov/pubmed/26728568
